You are a reputable and sought-after agency, and you receive a query from an aspiring writer. You request a partial, then decline politely, using a form letter (no doubt a nice one). Aspiring Writer swallows her dismay, and submits something else. Same result. And again. At what point should Aspiring Writer sigh and say, “It was not meant to be”? Would you ever say, “Please stop sending me queries” (which translates to, “You can’t write”)? Do you keep a list, and flinch when you see a particular return address? Or will you allow Aspiring Writer to keep submitting indefinitely, in the shared hope that her writing is improving and eventually she’ll get it right?
A lot of the authors I represent now were rejected at one point or another . . . by me. If you’ve done your research and you know for a fact that the agent you are targeting represents the work you are writing, then I see nothing wrong with continuing to submit to her. Bear in mind, however, that names do start to become familiar and we do keep lists of our submissions and rejections. So if you are getting rejected and do decide to resubmit, make sure that the next book is even stronger than the last. And, if the agent took the effort to give you a detailed rejection, then really make the effort to hear and understand what she said and see that your next submission matches that.
Also bear in mind that your work can very well be publishable, but I might not be the right agent to make that happen. It’s always best to read some of the books that an agent represents and target as many agents as possible. Finding an agent is so often about finding that person who truly understands your work.
Truth though . . . I have asked authors to stop submitting to me. They are usually the ones who don’t pay attention to what I’m representing and get belligerent because of the letters I’m sending. With some there seems to be an idea that because they’ve sent me so much work I owe them representation.